Ankylosing spondylitis (AS), also known as ankylosing spondylosis, is a chronic inflammatory disease that primarily affects the spine and sacroiliac joints. It can also affect other joints, such as the hips, shoulders, and knees, as well as other organs, such as the eyes and heart.
AS typically begins in early adulthood and is more common in men than women. It is characterized by inflammation of the joints and ligaments that attach to the spine, leading to pain and stiffness in the affected area. Over time, the inflammation can cause the bones in the spine to fuse together, resulting in a rigid, immobile spine. This fusion can lead to a hunched posture and a loss of flexibility in the spine.
The exact cause of AS is not known, but it is believed to be related to genetic and environmental factors. There is no cure for AS, but treatment can help manage the symptoms and prevent complications. Treatment options may include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, biologic medications, physical therapy, and surgery in severe cases.
